Women’s handbags have become the mainstay of the luxury industry, generating well over $10B a year in revenues. San Francisco has no dearth of companies designing, and sometimes manufacturing, bags locally, but most have an urban, not luxury sensibility. We have more manufacturers than any place with the possible exception of Australia. To mention but a few:

There is a newcomer to this list: Rickshaw Bagworks

Update (2012-07-13):

Add to the list:

Update (2013-08-07):

And some more: